I can only agree that more formal studies of LDN's efficacy would be welcome. Unfortunately, the drug companies won't fund them since it is out of patent and they can't make money on it and, worse from their perspective, if its efficacy were demonstrated in trials, its use would displace drugs that cost thousands of dollars per month for one that costs $7 to $25 per month (depending on where you get it). So from their perspective LDN is a pact with the devil. That leaves publicly funded sources like Penn State and Stanford and a few other research centers around the world.
What that leaves us with is a mountain of anecdotal evidence. Unlike some, I don't break out in a rash at taking this kind of evidence seriously. For one thing, there is so much of it. Here are a couple of links that will take you to databases of LDN users, the reason they take it, and how they feel about it. I just came across one that was new to me: https://www.patientslikeme.com/treatmen ... ws?brand=f
Another, larger database that has a little more polish may be found here: http://www.ldndatabase.com/index.html
This site also contains on its home page the well known video in which a fellow in a white jacket explains naltrexone, low dose naltrexone, and the rebound effect that causes our opioid receptors to be flooded with endorphins with the consequent sense of well-being and how this mediates our immune systems. Some of us practically have it memorized but it is required viewing for anyone interested in LDN who has not seen it.
One thing to keep in mind. While the efficacy of LDN has been the focus of only a few drug trials, its safety is quite another matter. The FDA has found naltrexone to be safe at doses almost 100 times the LDN dose. So, this much can be said with certainty: low dose naltrexone may or may not help you but IT WILL NOT HURT YOU. When you think about it, that's a lot more than many of the FDA approved treatments, for MS as an example, can say. We would certainly like more studies, but let's not be too ready to put our light under a basket. This stuff is working wonders for many, many people and you have nothing to lose by trying it. Just don't mix it with opiates. Simple rule.
So go to the databases and have a peek. Wander about. I think you'll be impressed with all the good news.
My best to you all.